Publications

Publications 1999 - 2004

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254. Smith, T. R., Dennis, E. A., Lennarz, W., and Lane, M. D., Phospholipase A₂ structure and function, in Encyclopedia of Biological Chemistry, Elsevier, Oxford, 297-300 (2004).

253. Lucas, K. K., and Dennis, E. A., The ABC's of group IV cytosolic phospholipase A₂, Biochim Biophys Acta, 1636, 213-218 (2004). PMID: 15164769.

252. Kokotos, G., Six, D. A., Loukas, V., Smith, T., Constantinou-Kokotou, V., Hadjipavlou-Litina, D., Kotsovolou, S., Chiou, A., Beltzner, C. C., and Dennis, E. A., Inhibition of group IVA cytosolic phospholipase A₂ by novel 2-oxoamides in vitro, in cells, and in vivo, J Med Chem, 47, 3615-3628 (2004). PMID: 15214789.

251. Boegeman, S. C., Deems, R. A., and Dennis, E. A., Phospholipid binding and the activation of group IA secreted phospholipase A₂, Biochemistry, 43, 3907-3916 (2004). PMID: 15049698.

250. Dennis, E. A., and Witztum, J. L., The new era in lipid science and medicine, J Lipid Res, 44, 1267-1267 (2003). http://www.jlr.org/cgi/content/full/44/7/1267

249. Balboa, M. A., Gaietta, G., Shirai, Y., Ellisman, M. H., Balsinde, J., and Dennis, E. A., Localization of group V phospholipase A₂ in caveolin-enriched granules in activated P388D₁ macrophage-like cells, J Biol Chem, 278, 48059-48065 (2003). PMID: 12963740.

248. Phillips, R., Six, D. A., Dennis, E. A., and Ghosh, P., In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A₂ inhibitors, J Biol Chem, 278, 41326-41332 (2003). PMID: 12915403.

247. Six, D. A., and Dennis, E. A., Essential Ca²⁺-independent role of the group IVA cytosolic phospholipase A₂ C2 domain for interfacial activity, J Biol Chem, 278, 23842-23850 (2003). PMID: 12672805.

246. Bradshaw, R. A., and Dennis, E. A., Handbook of Cell Signaling, Academic Press/Elsevier, Vol. 1, pp 1-747; Vol. 2, pp 1-899; Vol. 3, pp 1-709. Also, CD-Rom Version (2003).

245. Bradshaw, R. A., and Dennis, E. A., Cell signaling: yesterday, today and tomorrow, in Handbook of Cell Signaling (E. A. Dennis, and R. A. Bradshsaw eds.), Academic Press/Elsevier, 1, 1-3 (2003).

244. Balsinde, J., and Dennis, E. A., Phospholipase A₂ signaling and arachidonic acid release, in Handbook of Cell Signaling (R. Bradshsaw, and E. A. Dennis eds.), Academic Press/Elsevier, Vol. 2, 261-263 (2003).

243. Whiles, J. A., Deems, R. A., Vold, R. R., and Dennis, E. A., Bicelles in structure-function studies of membrane associated proteins, Bioorg Chem, 30, 431-442 (2003). PMID: 12642127.

242. Balsinde, J., Winstead, M. V., and Dennis, E. A., Phospholipase A₂ regulation of arachidonic acid mobilization, FEBS Lett, 531, 2-6 (2002). PMID: 12401193.

241. Balboa, M. A., Varela-Nieto, I., Killermann-Lucas, K., and Dennis, E. A., Expression and function of brain-specific phospholipase A₂, FEBS Lett, 531, 12-17 (2002). PMID: 12401195.

240. Kokotos, G., Kotsovolou, S., Six, D. A., Constantinou-Kokotou, V., Beltzner, C. C., and Dennis, E. A., Novel 2-oxo amide inhibitors of human group IVA phospholipase A₂, J Med Chem, 45, 2891-2893 (2002). PMID: 12086476.

239. Friedman, P., Hörkkö, S., Steinberg, D., Witztum, J. L., and Dennis, E. A., Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids: importance of Schiff base formation and aldol condensation, J Biol Chem, 277, 7010-7020 (2002). PMID: 11744722.

238. Boullier, A., Bird, D. A., Chang, M., Dennis, E. A., Friedman, P., Gillotte, K. L., Hörkkö, S., Palinski, W., Quehenberger, O., Shaw, P., Steinberg, D., Terpstra, V., and Witztum, J. L., Scavenger receptors, oxidized LDL, and atherosclerosis, Ann N Y Acad Sci, 947, 214-222 (2002). PMID: 11795269.

237. Yang, H. C., Mosior, M., and Dennis, E. A., Design and development of a selective assay system for the phospholipase A₂ superfamily, in Enzyme Technologies for Pharmaceutical and Biotechnological Applications (H. A. Kirst, W. K. Yeh, and M. J. Zimijewski eds.), 379-396 (2001).

236. Bernatchez, P. N., Winstead, M. V., Dennis, E. A., and Sirois, M. G., VEGF stimulation of endothelial cell PAF synthesis is mediated by group 14kDa secretory phospholipase A₂, Br J Pharmacol, 134, 197-205 (2001). PMID: 11522612.

235. Balboa, M. A., Balsinde, J., and Dennis, E. A., Inflammatory activation of prostaglandin production by microglial cells antagonized by amyloid peptide, Biochem Biophys Res Commun, 280, 558-560 (2001). PMID: 11162555.

234. Six, D. A., and Dennis, E. A., The expanding superfamily of phospholipase A₂ enzymes: classification and characterization, Biochim Biophys Acta, 1488, 1-19 (2000). PMID: 11080672.

233. Balsinde, J., Balboa, M. A., and Dennis, E. A., Identification of a third pathway for arachidonic acid mobilization and prostaglandin production in activated P388D₁ cells, J Biol Chem, 275, 22544-22549 (2000). PMID: 10811815.

232. Winstead, M. V., Balsinde, J., and Dennis, E. A., Calcium-independent phospholipase A₂: structure and function, Biochim Biophys Acta, 1488, 28-39 (2000). PMID: 11080674.

231. Wang, A., Johnson, C. A., Ellisman, M. H., and Dennis, E. A., Subcellular localization and PKC-dependent regulation of the human lysophospholipase A / acyl-protein thioesterase in WISH cells, Biochim Biophys Acta, 1484, 207-214 (2000). PMID: 10760470.

230. Balsinde, J., Balboa, M. A., Li, W. H., Llopis, L., and Dennis, E. A., Cellular regulation of cytosolic group IV phospholipase A₂ by phosphatidylinositol bisphosphate levels, J Immunol, 164, 5398-5402 (2000). PMID: 10799904. http://www.ncbi.nlm.nih.gov/pubmed/10799904

229. Boullier, A., Gillotte, K. L., Hörkkö, S., Green, S. R., Friedman, P., Dennis, E. A., Witztum, J. L., Steinberg, D., and Quehenberger, O., The binding of oxidized LDL to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein, J Biol Chem, 275, 9163-9169 (2000). PMID: 10734051.

228. Balsinde, J., Balboa, M. A., Yedgar, S., and Dennis, E. A., Group V phospholipase A₂-mediated oleic acid mobilization in lipopolysaccharide-stimulated P388D₁ macrophages, J Biol Chem, 275, 4783-4786 (2000). PMID: 10671511.

227. Balboa, M. A., Balsinde, J., and Dennis, E. A., Phosphorylaton of cytosolic group IV phospholipase A₂ is necessary but not sufficient for arachidonic acid release in P388D₁ macrophages, Biochem Biophys Res Commun, 267, 145-148 (2000). PMID: 10623589.

226. Johansen, B., Rakkestad, K., Balboa, M. A., and Dennis, E. A., Expression of cytosolic and secreted forms of phospholipase A₂ and cyclooxygenases in human placenta, fetal membranes and chorionic cell lines, Prostaglandins Other Lipid Mediat, 60, 119-125 (2000). PMID: 10751642.

225. Bianco, I. D., Balsinde, J., Beltramo, D. M., Castagna, L. F., Landa, C. A., and Dennis, E. A., Chitosan-induced phospholipase A₂ activation and arachidonic acid mobilization in P388D₁ Macrophages, FEBS Lett, 466, 292-294 (2000). PMID: 10682846.

224. Balsinde, J., Balboa, M. A., and Dennis, E. A., Group IV cytosolic phospholipase A₂ activation by diacylglycerol pyrophosphate in murine P388D₁ macrophages, Ann N Y Acad Sci, 905, 11-15 (2000). PMID: 10818437.

223. Lefkowitz, L. J., Shinohara, H., and Dennis, E. A., Human group V phospholipase A₂ expression in Pichia pastoris and its role in eicosanoid generation, in Ernst Schering Research Foundation Workshop 31: Advances in Eicosanoid Research (C. N. Serhan, and H. D. Perez eds.), Springer-Verlag, Heidelberg, 25-52 (2000). PMID: 10943326.

222. Dennis, E. A., Phospholipase A₂ in eicosanoid generation, Am J Respir Crit Care Med, 161, S32-S35 (2000). PMID: 10673223.

221. Chang, M., Bergmark, C., Laurila, A., Hörkkö, S., Han, K. H., Friedman, P., Dennis, E. A., and Witztum, J. L., Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition, Proc Natl Acad Sci U S A, 96, 6353-6358 (1999). PMID: 10339591.

220. Bird, D. A., Gillotte, K. L., Heorkkeo, S., Friedman, P., Dennis, E. A., Witztum, J. L., and Steinberg, D., Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: implications with respect to macrophage recognition of apoptotic cells, Proc Natl Acad Sci U S A, 96, 6347-6352 (1999). PMID: 10339590.

219. Canne, L. E., Botti, P., Simon, R. J., Chen, Y., Dennis, E. A., and Kent, S. B. H., Chemical protein synthesis by solid phase ligation of unprotected peptide segments, J Am Chem Soc, 121, 8720-8727 (1999). http://pubs.acs.org/cgi-bin/article.cgi/jacsat/1999/121/i38/pdf/ja9836287.pdf

218. Balboa, M. A., Balsinde, J., Johnson, C. A., and Dennis, E. A., Regulation of arachidonic acid mobilization in lipopolysaccharide-activated P388D₁ macrophages by adenosine triphosphate, J Biol Chem, 274, 36764-36768 (1999). PMID: 10593984.

217. Wang, A., and Dennis, E. A., Mammalian lysophospholipases, Biochim Biophys Acta, 1439, 1-16 (1999). PMID: 10395961.

216. Johnson, C. A., Balboa, M. A., Balsinde, J., and Dennis, E. A., Regulation of cyclooxygenase-2 expression by phosphatidate phosphohydrolase in human amnionic WISH cells, J Biol Chem, 274, 27689-27693 (1999). PMID: 10488110.

215. Lefkowitz, L. J., Deems, R. A., and Dennis, E. A., Expression of group IA phospholipase A₂ in Pichia pastoris: identification of a phosphatidylcholine activator site using site-directed mutagenesis, Biochemistry, 38 (43), 14174-14184 (1999). PMID: 10571991.

214. Hörkkö, S., Bird, D. A., Miller, E., Itabe, H., Leitinger, N., Subbanagounder, G., Berliner, J., Friedman, P., Dennis, E. A., Curtiss, L. K., Palinski, W., and Witztum, J. L., Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibits macrophage uptake of oxidized low density lipoproteins, J Clin Invest, 103, 117-128 (1999). PMID: 9884341.

213. Balsinde, J., Shinohara, H., Lefkowitz, L. J., Johnson, C. A., Balboa, M. A., and Dennis, E. A., Group V phospholipase A₂ dependent induction of cyclooxygenase-2 in macrophages, J Biol Chem, 274, 25967-25970 (1999). PMID: 10473537.

212. Yang, H. C., Mosior, M., Johnson, C. A., Chen, Y., and Dennis, E. A., Group-specific assays that distinguish between the four major types of mammalian phospholipase A₂, Anal Biochem, 269, 278-288 (1999). PMID: 10221999.

211. Wang, A., Yang, H. C., Friedman, P., Johnson, C. A., and Dennis, E. A., A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization, Biochim Biophys Acta, 1437, 157-169 (1999). PMID: 10064899.

210. Yang, H. C., Mosior, M., Ni, B., and Dennis, E. A., Regional distribution, ontogeny, purification and characterization of a Ca²⁺-independent phospholipase A₂ from rat brain, J Neurochem, 73, 1278-1287 (1999). PMID: 10461922.

209. Ghomashchi, F., Loo, R. W., Balsinde, J., Bartoli, F., Apitz-Castro, R., Clark, J. D., Dennis, E. A., and Gelb, M. H., Trifluoromethyl ketones and fluoromethyl phosphonates as selective inhibitors of group IV and VI phospholipases A₂: structure-function studies with vesicle, micelle, and membrane assays, Biochim Biophys Acta, 1420, 45-56 (1999). PMID: 10446289.

208. Shinohara, H., Balboa, M. A., Johnson, C. A., Balsinde, J., and Dennis, E. A., Regulation of delayed prostaglandin production in activated P388D₁ macrophages by group IV cytosolic and group V secretory phospholipase A₂s, J Biol Chem, 274, 12263-12268 (1999). PMID: 10212194.

207. Balboa, M. A., Balsinde, J., Dillon, D. A., Carman, G. M., and Dennis, E. A., Proinflammatory macrophage-activating properties of the novel phospholipid diacylglycerol pyrophosphate, J Biol Chem, 274, 522-526 (1999). PMID: 9867874.

206. Balsinde, J., Balboa, M. A., Insel, P. A., and Dennis, E. A., Regulation and inhibition of phospholipase A₂, Annu Rev Pharmacol Toxicol, 39, 175-189 (1999). PMID: 10331081.

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