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Recent Publications (2005 - present)
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  • 307. Bradshaw, R.A. and Dennis, E.A. Handbook of cell signaling. 2nd edition. Vol 1, 2 and 3. Academic Press / Elsevier. Also web version (2009).
  • 306. Bradshaw, R.A. and Dennis, E.A., Cell signaling: yesterday, today and tomorrow, in Handbook of cell signaling. 2nd edition (R.A. Bradshaw and E.A. Dennis, Edits.), Elsevier, In press (2009).
  • 305. Barbayianni, E., Stephens, D., Grkovich, A., Magrioti, V., Hsu, Y.H., Dolatzas, P., Kalogiannidis, D., Dennis, E.A. and Kokotos, G., 2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides, Bioorg Med Chem, 17, 4833-4843 (2009). PMID: 19443224.
  • 304. Blaho, V.A., Buczynski, M.W., Brown, C.R. and Dennis, E.A., Lipidomics analysis of dynamic eicosanoid responses during the induction and resolution of lyme arthritis, J Biol Chem, 284, 21599-21612 (2009). PMID: 19487688.
  • 303. Grkovich, A., Armando, A., Quehenberger, O. and Dennis, E.A., TLR-4 mediated group IVA phospholipase A2 activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent, Biochim Biophys Acta, Epub ahead of print. DOI: 10.1016/j.bbalip.2009.1002.1002 (2009). PMID: 19230851.
  • 302. Buczynski, M.W., Dumlao, D.S. and Dennis, E.A., An integrated omics analysis of eicosanoid biology, J Lipid Res, 50, 1015-1038 (2009). PMID: 19244215.
  • 301. Gupta, S., Maurya, M.R., Stephens, D.L., Dennis, E.A. and Subramaniam, S., An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis, Biophys J, 96, 4542-4551 (2009). PMID: 19486676.
  • 300. Burke, J.E., Babakhani, A., Gorfe, A.A., Kokotos, G., Li, S., Woods, V.L., Jr., McCammon, J.A. and Dennis, E.A., Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry, J Am Chem Soc, 131, 8083-8091 (2009). PMID: 19459633.
  • 299. Balsinde, J. and Dennis, E.A., Role of phospholipase A2 forms in arachidonic acid mobilization and eicosanoid generation, in Handbook of Cell Signaling, 2nd Edition, (R.A. Bradshaw and E.A. Dennis, Edits.) Elsevier, in press (2009).
  • 298. Grkovich, A. and Dennis, E.A., Phosphatidic acid phosphohydrolase in the regulation of inflammatory signaling, Advan Enzyme Regul, 49, 114-120 (2009). PMID: 19640413.
  • 297. Hsu, Y.H., Burke, J.E., Li, S., Woods, V.L., Jr. and Dennis, E.A., Localizing the membrane binding region of group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry, J Biol Chem, Epub ahead of print. DOI: 1074/jbc.M1109.021857 (2009). PMID: 19556238.
  • 296. Kalyvas, A., Baskakis, C., Magrioti, V., Constantinou-Kokotou, V., Stephens, D., López-Vales, R., Lu, J.Q., Yong, V.W., Dennis, E.A., Kokotos, G. and David, S., Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis, Brain, 132, 1221-1235 (2009). PMID: 19218359.
  • 295. Dennis, E.A., Lipidomics joins the omics evolution, Proc Natl Acad Sci U S A, 106, 2089-2090 (2009). PMID: 19211786.
  • 294. Burke, J.E. and Dennis, E.A., Phospholipase A2 Biochemistry, Cardiovasc Drugs Ther, 23, 49-59 (2009). PMID: 18931897.
  • 293. Burke, J.E. and Dennis, E.A., Phospholipase A2 structure/function, mechanism and signaling, J Lipid Res, 50 Suppl, S237-S242 (2009). PMID: 19011112.
  • 292. Dennis, E.A., Founding, early history, and transformation of the Journal of Lipid Research to an ASBMB journal, J Lipid Res, 50 Suppl, S3-8 (2009). PMID: 19116414.
  • 291. Fahy, E., Subramaniam, S., Murphy, R.C., Nishijima, M., Raetz, C.R., Shimizu, T., Spener, F., van Meer, G., Wakelam, M.J. and Dennis, E.A., Update of the LIPID MAPS comprehensive classification system for lipids, J Lipid Res, 50 Suppl, S9-14 (2009). PMID: 19098281.
  • 290. Prevost, N., Mitsios, J.V., Kato, H., Burke, J.E., Dennis, E.A., Shimizu, T. and Shattil, S.J., Group IVA cytosolic phospholipase A2 (cPLA2{alpha}) and integrin {alpha}IIb{beta}3 reinforce each other's functions during {alpha}IIb{beta}3 signaling in platelets, Blood, 113, 447-457 (2009). PMID: 18840708.
  • 289. Baskakis, C., Magrioti, V., Cotton, N., Stephens, D., Constantinou-Kokotou, V., Dennis, E.A. and Kokotos, G., Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes, J Med Chem, 51, 8027-8037 (2008). PMID: 19053783.
  • 288. Quehenberger, O., Armando, A., Dumlao, D., Stephens, D. and Dennis, E.A., Lipidomics analysis of essential fatty acids in macrophages, Prostaglandins Leukot Essent Fatty Acids, 79, 123-129 (2008). PMID: 18996688.
  • 287. Burke, J.E., Hsu, Y.H., Deems, R.A., Li, S., Woods, V.L., Jr. and Dennis, E.A., A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2, J Biol Chem, 283, 31227-31236 (2008). PMID: 18753135.
  • 286. Antonopoulou, G., Barbayanni, E., Magrioti, V., Cotton, N., Stephens, D., Constantinou-Kokotou, V., Dennis, E.A. and Kokotos, G., Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of phospholipase A2 enzymes, Bioorg Med Chem, 16, 10257-10269 (2008). PMID: 18993078.
  • 285. López-Vales, R., Navarro, X., Shimizu, T., Baskakis, C., Kokotos, G., Constantinou-Kokotou, V., Stephens, D., Dennis, E.A. and David, S., Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury, Brain, 131, 2620-2631 (2008). PMID: 18718965.
  • 284. Burke, J.E., Karbarz, M.J., Deems, R., Li, S., Woods, V.L., Jr. and Dennis, E.A., Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry, Biochemistry, 47, 6451-6459 (2008). PMID: 18500818.
  • 283. Jacobsen, F.E., Buczynski, M.W., Dennis, E.A. and Cohen, S.M., A macrophage cell model for selective metalloproteinase inhibitor design, Chembiochem, 9, 2087-2095 (2008). PMID: 18666306.
  • 282. Antonopoulou, G., Magrioti, V., Stephens, D., Constantinou-Kokotou, V., Dennis, E.A. and Kokotos, G., Synthesis of 2-oxoamides based on sulfonamide analogs of gamma-amino acids and their activity on phospholipase A2, J Pept Sci, 10, 1111-1120 (2008). PMID: 18618424.
  • 281. Hsu, Y. H., Burke, J. E., Stephens, D. L., Deems, R. A., Li, S., Asmus, K. M., Woods, V. L., Jr., and Dennis, E. A., Calcium binding rigidifies the C2 domain and the intra-domain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry, J Biol Chem, 283, 9820-7 (2008). PMID: 18211893.
  • 280. Harkewicz, R., Hartvigsen, K., Almazan, F., Dennis, E. A., Witztum, J. L., and Miller, Y. I., Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized LDL, J Biol Chem, 283, 10241-10251 (2008). PMID: 18263582.
  • 279. Moutevelis-Minakakis, P., Neokosmidi, A., Filippakou, M., Stephens, D., Dennis, E. A., and Kokotos, G., Synthesis of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues and their activity against phospholipase A2, J Pept Sci, 13, 634-641 (2007). PMID: 17631670.
  • 278. Schmelzer, K., Fahy, E., Deems, R., Subramaniam, S., and Dennis, E. A., The LIPID MAPS initiative in lipidomics, in Methods in Enzymology, 432, 169-181 (2007). PMID: 17954217.
  • 277. Deems, R. A., Buczynski, M. W., Bowers-Gentry, R. C., Harkewicz, R., and Dennis, E. A., Detection and quantitation of eicosanoids via high performance liquid chromatography/electrospray ionization mass spectrometry, in Methods in Enzymology, Academic Press, 432, 59-82 (2007). PMID: 17954213.
  • 276. Buczynski, M. W., Stephens, D. L., Bowers-Gentry, R. C., Grkovich, A., Deems, R. A., and Dennis, E. A., TLR-4 and sustained calcium agonists synergistically produce eicosanoids independant of protein synthesis in RAW264.7 cells., J Biol Chem, 282, 22834-22847 (2007). PMID: 17535806.
  • 275. Six, D. A., Barbayianni, E., Loukas, V., Constantinou-Kokotou, V., Hadjipavlou-Litina, D., Stephens, D. L., Wong, A. C., Magrioti, V., Moutevelis-Minakakis, P., Baker, S. F., Dennis, E. A., and Kokotos, G., Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2, J Med Chem, 50, 4222-4235 (2007). PMID: 17672443.
  • 274. Harkewicz, R., Fahy, E., Andreyev, A., and Dennis, E. A., Arachidonate-derived dihomo-prostaglandin production observed in endotoxin stimulate macrophage-like cells, J Biol Chem, 282, 2899-2910 (2007). PMID: 17135246.
  • 273. Sud, M., Fahy, E., Cotter, D., Brown, A., Dennis, E. A., Glass, C. K., Merrill, A. H., Jr., Murphy, R. C., Raetz, C. R., Russell, D. W., and Subramaniam, S., LMSD: LIPID MAPS structure database, Nucleic Acids Res, 35, D527-532 (2007). PMID: 17098933.
  • 272. Schaloske, R. H., and Dennis, E. A., The phospholipase A2 superfamily and its group numbering system, Biochim Biophys Acta, 1761, 1246-1259 (2006). PMID: 16973413.
  • 271. Grkovich, A., Johnson, C. A., and Dennis, E. A., Lipopolysaccharide Induced Cyclooxygenase-2 Expression in Human U937 Macrophages is Phosphatidic Acid Phosphohydrolase-1 Dependent, J Biol Chem, 281, 32,978-932,987 (2006). PMID: 16950767.
  • 270. Stephens, D. L., Barbayianni, E., Constantinou-Kokotou, V., Peristeraki, A., Cooper, J., Harkewicz, R., Deems, R. A., Dennis, E. A., and Kokotos, G., Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides, J Med Chem, 49, 2821-2828 (2006). PMID: 16640343.
  • 269. Raetz, C. R., Garrett, T. A., Reynolds, C. M., Shaw, W. A., Moore, J. D., Smith, D. C., Jr., Ribeiro, A. A., Murphy, R. C., Ulevitch, R. J., Fearns, C., Reichart, D., Glass, C. K., Benner, C., Subramaniam, S., Harkewicz, R., Bowers-Gentry, R. C., Buczynski, M. W., Cooper, J. A., Deems, R. A., and Dennis, E. A., Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4, J Lipid Res, 47, 1097-1111 (2006). PMID: 16479018.
  • 268. Yaksh, T. L., Kokotos, G., Svensson, C. I., Stephens, D. L., Kokotos, C., Fitzsimmons, B., Hadjipavlou-Litina, D., Hua, X. Y., and Dennis, E. A., Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal PGE2 release, J Pharmacol Exp Ther, 316, 466-475 (2006). PMID: 16203828.
  • 267. Kessen, U. A., Schaloske, R. H., Stephens, D. L., Killermann-Lucas, K., and Dennis, E. A., PGE2 release is independent of upregulation of group V phospholipase A2 during long-term stimulation of P388D1 cells with LPS, J Lipid Res, 46, 2488-2496 (2005). PMID: 16150819.
  • 266. Boullier, A., Friedman, P., Harkewicz, R., Hartvigsen, K., Green, S. R., Almazan, F., Dennis, E. A., Steinberg, D., Witztum, J. L., and Quehenberger, O., Phosphorylcholine as a Pattern Recognition Ligand for CD36, J Lipid Res, 46, 969-976 (2005). PMID: 15722561.
  • 265. Rapaka, R. S., Piomelli, D., Spiegel, S., Barzan, N., and Dennis, E. A., Targeted lipidomics: signaling lipids and drugs of abuse, Prostaglandins Other Lipid Mediat, 223-234 (2005). PMID: 16099407.
  • 264. Winstead, M. V., Killermann-Lucas, K., and Dennis, E. A., Group IV cytosolic phospholipase A2 mediates arachidonic acid release in H9c2 rat cardiomyocyte cells in response to hydrogen peroxide, Prostaglandins Other Lipid Mediat, 78, 55-66 (2005). PMID: 16303605.
  • 263. Bowers-Gentry, R. C., Deems, R., Harkewicz, R., and Dennis, E. A., Eicosanoid lipidomics, in Functional Lipidomics (L. Feng, and G. Prestwich eds.), CRC Press/Taylor & Francis Group, Boca Raton, FL, 79-94 (2005).
  • 262. Dennis, E. A., Brown, H. A., Deems, R. A., Glass, C. K., Merrill, A. H., Jr., Murphy, R. C., Raetz, C. R., Shaw, W., Subramaniam, S., Russell, D. W., vanNieuwenhze, M. S., White, S. H., Witztum, J. L., and Wooley, J., The LIPID MAPS approach to lipidomics, in Functional Lipidomics (L. Feng, and G. Prestwich eds.), CRC Press/Taylor & Francis Group, Boca Raton, FL, 1-15 (2005).
  • 261. Fahy, E., Subramaniam, S., Brown, H. A., Glass, C. K., Merrill, A. H., Jr., Murphy, R. C., Raetz, C. R., Russell, D. W., Seyama, Y., Shaw, W., Shimizu, T., Spener, F., van Meer, G., VanNieuwenhze, M. S., White, S. H., Witztum, J. L., and Dennis, E. A., A comprehensive classification system for lipids, J Lipid Res, 46, 839-861 (2005). Reprinted in Eur. J. Lipid Sci. & Technol. 107, 337-364 (2005). PMID: 15722563.
  • 260. Shirai, Y., Balsinde, J., and Dennis, E. A., Localization and functional interrelationships of cytosolic group IV, secretory group V, and Ca2+-independent group VI phospholipase A2s in macrophages using GFP/RFP constructs, Biochim Biophys Acta, 1735, 119-129 (2005). PMID: 15967714.
  • 259. Lucas, K. K., Svensson, C. I., Hua, X. Y., Yaksh, T. L., and Dennis, E. A., Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2, Br J Pharmacol, 144, 940-952 (2005). PMID: 15685208.
  • 258. Constantinou-Kokotou, V., Peristeraki, A., Kokotos, G., Six, D. A., and Dennis, E. A., Synthesis and activity of 2-oxoamides containing long chain beta-amino acids, J Pept Sci, 11, 431-435 (2005). PMID: 15635664.
  • 257. Svensson, C. I., Lucas, K. K., Hua, X.-Y., Powell, H. C., Dennis, E. A., and Yaksh, T. L., Spinal phospholipase A2 in inflammatory hyperalgesia: role of the small, secreted sPLA2s, Neuroscience, 133, 543-553 (2005). PMID: 15885922.
  • 256. Schaloske, R. H., Provins, J. W., Kessen, U. A., and Dennis, E. A., Molecular characterization of the lipopolysaccharide/platelet activating factor and zymosan induced pathways leading to prostaglandin production in P388D1 macrophages, Biochim Biophys Acta, 1687, 64-75 (2005). PMID: 15708354.
  • 255. Lucas, K. K., and Dennis, E. A., Distinguishing phospholipase A2 types in biological samples by employing group-specific assays in the presence of inhibitors, Prostaglandins Other Lipid Mediat, 77, 235-248 (2005). PMID: 16099408.
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