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Recent Publications (2010 - present)

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  • 345. Pang XY, Cao J, Addington L, Lovell S, Battaile KP, Zhang N, Maheshwar Rao JLU, Dennis EA, Moise AR (2012) Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad. J Biol Chem, Epub ahead of print.
  • 344. Van Dijk RA, Kolodgie F, Ravandi A, Harkewicz R, Hu PP, Prasad A, Mahmud E, Dennis EA, Curtis LK, Witztum JL, Virmani R, Tsimikas S (2012) Differential expression of oxidation-specific epitopes and lipoprotein(a) in progressing and ruptured human atherosclerotic lesions. J Lipid Res, Epub ahead of print.
  • 343. Spann NJ, Garmire L, McDonald JF, Meyers DS, Milne SB, Shibata N, Reichart D, Fox JN, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown A, Dennis EA, Li AC, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass C (2012) Desmosterol accumulation in macrophage foam cells coordinately regulates LXR and SREBP gene expression and suppresses inflammatory responses. Cell, in press.
  • 342. Dumlao DS, Cunningham AM, Wax LE, Norris PC, Hughes-Hanks JM, Halpin RE, Lett KM, Blaho VA, Mitchell WJ, Fritsche KL, Dennis EA, Brown CR (2012) Dietary fish oil substitution dramatically alters the eicosanoid profile in ankle joints of mice during Lyme infection. J Nutrition, 142, 1582-9. PMID22695969
  • 341. Norris PC, Dennis EA (2012) Omega-3 fatty acids cause dramatic changes in TLR-4 and purinergic signaling. Proc Natl Acad Sci U S A, 109, 6721-6. PMID22586114
  • 340. Gregus AM, Dumlao DS, Doolen S, Takasusuki T, Buczynski MW, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL (2012) Spinal 12-lipoxygenase-derived Hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A, 109, 6721-6. PMID22493235
  • 339. Grover RK, Cheng J, Peng Y, Jones T, Ruiz D, Ulevitch RJ, Glass J, Dennis EA, Salomon IH, Lerner RA (2012) The co-stimulatory immunogen LPS induces the B-cell clones that infiltrate transplanted human kidneys. Proc Natl Acad Sci U S A, 109, 6036-41. PMID22492977
  • 338. Sabido E, Quehenberger O, Shen Q, Chang V, Shah I, Armando A, Andreyev A, Vitek O, Dennis EA, Aebersold R (2012) Targeted proteomics of the eicosanoid biosynthetic pathway completes an integrated genomics-proteomics-metabolomics picture of cellular metabolism. Mol Cell Proteomics, Epub ahead of print. PMID22361236
  • 337. Mouchlis VD, Michopoulou V, Constantinou-Kokotou V, Mavromoustakos T, Dennis EA, Kokotos G (2012) Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics. J Chem Inf Model, 52, 243-54. PMID22196172
  • 336. Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, Wang X, Hughes G, Wei X, Molday RS, Shaw PX, Dennis EA, Zhang K (2011) Essential role of ELOVL4 in very long chain fatty acid synthesis and retinal function. J Biol Chem, 287, 11469-80. PMID22199362
  • 335. Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson C, Corr M, Yaksh TL (2011) Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain, 152, 2881-91. PMID22019135
  • 334. Quehenberger O, Dennis EA (2011) The human plasma lipidome. New England J Med, 365, 1812-23. PMID22070478
  • 333. López-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayanni E, Antonopoulou G, Baskakis C, Rathore KI, Constantinou-Kokotou V, Stephens D, Shimizu T, Dennis EA, Kokotos G, David S (2011) Phospholipase A2 superfamily members play divergent roles after spinal cord injury FASEB J, 25, 4240-52. PMID21868473
  • 332. Dennis EA, Cao J, Hsu YH, Magrioti V, Kokotos G (2011) Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev, 111 (10), 6130-6185. PMID21910409
  • 331. Quehenberger O, Yamashita T, Armando AM, Dennis EA, Palinski W (2011) Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids. Am J Obstet Gynecol, 205:156, e15-25. PMID21621186
  • 330. Norris PC, Reichart D, Dumlao D, Glass CK, Dennis EA (2011) Specificity of eicosanoid production depends on the TLR-4 stimulated macrophage phenotype. J Leukocyte Biology, 90, 53-74.PMID21653236
  • 329. Cao J, Hsu YH, Li S, Woods VL, Jr., Dennis EA (2011) Lipoprotein-associated phospholipase A2 Interacts with phospholipid vesicles via a surface-disposed hydrophobic a-Helix. Biochemistry, 50, 5314-21.PMID21553808
  • 328. Dennis EA, Bradshaw RA, Editors (2011) Transduction mechanisms in cellular signaling. Academic Press/Elsevier. 610 pages.
  • 327. Dennis EA, Bradshaw RA, Editors (2011) Transduction mechanisms in cellular signaling. Academic Press/Elsevier. 610 pages.
  • 326. Dennis EA, Bradshaw RA, Editors (2011) Transduction mechanisms in cellular signaling. Academic Press/Elsevier. 610 pages.
  • 325. Bradshaw RA, Dennis EA, Editors (2011) Functioning of transmembrane receptors in cell signaling. Academic Press/Elsevier. 456 pages.
  • 324. Dennis EA, Bradshaw RA (2011) Signaling in development and disease in Intercellular signaling in development and disease, E.A. Dennis and R.A. Bradshaw, Editors. Academic Press/Elsevier, 1-7.
  • 323. Bradshaw RA, Dennis EA (2011) Organelle signaling in Regulation of organelle and cell compartment signaling, R.A. Bradshaw and E.A. Dennis, Editors. Academic Press / Elsevier, 1-8.
  • 322. Dennis EA, Bradshaw RA (2011) Intracellular signaling in Transduction mechanisms in cellular signaling, E.A. Dennis and R.A. Bradshaw, Editors. Academic Press/Elsevier, 1-7.
  • 321. Bradshaw RA, Dennis EA (2011) Transmembrane receptors and their signaling properties in Functioning of transmembrane receptors in cell signaling, R.A. Bradshaw and E.A. Dennis, Editors. Academic Press/Elsevier, 1-7.
  • 320. Quehenberger O, Dennis EA (2011) GC/MS analysis of fatty acids. Biochim Biophys Acta, 1811, 648-56. PMID21787881
  • 319. Dumlao DS, Buczynski MW, Norris PC, Harkewicz R, Dennis EA (2011) High-throughput lipidomic analysis of fatty acid derived eicosanoids and n-acylethanolamines. Biochim Biophys Acta, 1811, 724-36. PMID21689782
  • 318. Harkewicz R, Dennis EA (2011) Applications of mass spectrometry to lipids and membranes. Annu Rev Biochem, 80, 301-25.
  • 317. Dennis EA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Fahy E, Subramaniam S (2010) A mouse macrophage lipidome. J Biol Chem, 285, 39976-85. PMID20923771
  • 316. Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller YI (2010) Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high-cholesterol diet: macrophage binding and activation. J Biol Chem, 285, 32343-51. PMID20710028
  • 315. Quehenberger O, Armando A, Brown HA, Milne JS, Myers DS, Merrill AH, Bandyopadyhay S, Jones ND, Kelly S, Shaner RL, Sullards MC, Wang E, Murphy RC, Barkley RM, Leiker TJ, Raetz CR, Guan Z, Laird GM, Six DA, Russell DW, McDonald JG, Subramaniam S, Fahy E, Dennis EA (2010) Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res, 51, 3299-305. PMID20671299
  • 314. Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers DS, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, Raetz CR, Russell DW, Subramaniam S, Dennis EA (2010) Subcellular organelle lipidomics in TLR 4-activated macrophages. J Lipid Res, 51, 2785-97. PMID20574076
  • 313. Buczynski MW, Svensson C, Dumlao D, Fitzsimmons B, Shim JH, Scherbart T, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA (2010) Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. J Neurochem, 114, 981-93. PMID: 20492349
  • 312. Saito O, Svensson CI, Buczynski MW, Wegner K, Hua XY, Codeluppi S, Schaloske RH, Deems RA, Dennis EA, Yaksh TL (2010) Spinal glial Toll-like receptor 4-mediated nociception and production of prostaglandin E2 and TNF. Brit. J. Pharm, 160, 1754-64. PMID: 20649577
  • 311. Kokotos G, Hsu YH, Burke JE, Baskakis C, Kokotos CG, Magrioti V, Dennis EA (2010) Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem, 53, 3602-10. PMID: 20369880
  • 310. Harmon GS, Dumlao DS, Ng DT, Barrett KE, Dennis EA, Dong H, Glass CK (2010) Pharmacological correction of a defect in PPAR signaling ameliorates disease severity in CFTR-deficient mice. Nature Medicine, 16, 313-8. PMID: 20154695
  • 309. Andreyev AY, Shen Z, Guan Z, Ryan A, Fahy E, Subramaniam S, Raetz CR, Briggs S, Dennis EA (2010) Application of proteomic marker ensembles to subcellular organelle identification. Mol Cell Proteomics, 9, 388-402. PMID: 19884172
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