Table II Phospholipase A2 Groups Utilizing a Catalytic Serinea
Group		Initial/Common Sources	Alternate Names	Size	Ca2+	Characteristics	Human	Human NCBI
			Employed	(kDa)	Effects		Chromosome	Accession #
IV	A	Human U937 cells/platelets	cPLA2  a	85	<mM; membrane	C2 domain, a/b hydrolase	1q25 [65]	P47712
		RAW 264.7/rat kidney			translocation	regulatory phosphorylation
	B	Human pancreas/liver	cPLA2  b	114	<mM; membrane	C2 domain, a/b hydrolase	15 [66]	AAD32135
		heart/brain			translocation
	C	Human heart/skeletal muscle	cPLA2  g	61	None	Prenylated, a/b hydrolase	19 [66]	AAC32823
VI	A-1	P388D1 Macrophages, CHO	iPLA2 or iPLA2-A	84-85	None	Short splice, 8 ankyrin repeats	22q13.1 [66,27,67]	AAD41722
	A-2	Human B-lymphocytes, testis	iPLA2-B	88-90	None	Long splice, 7 ankyrin repeats	22q13.1  [66,27,67]	NP_003551
	B	Human heart/skeletal muscle	iPLA2  g or iPLA2-2	88	None	Membrane-bound	7q31 [68,70]	BAA94997
VII	A	Human/mouse/porcine	PAF-AH	45	None	Secreted, a/b hydrolase	N.D.	Q13093
		bovine plasma				Ser/His/Asp triad in VIIA and B
	B	Human/bovine liver/kidney	PAF-AH (II)	40	None	Intracellular, myristoylated	N.D.	Q99487
VIII	A	Human brain	PAF-AH Ib a1	26	None	Intracellular, G protein fold	N.D.	Q15102
			(subunit of trimer)			Ser/His/Asp triad, dimeric
	B	Human brain	PAF-AH Ib a2	26	None	Same as VIIIA; active as	11q23 [69]	Q29459
			(subunit of trimer)			heterodimer or homodimer
a Larger, typically intracellular enzymes that utilize a nucleophilic serine for hydrolytic cleavage with no disulfide bonds and no Ca2+ requirement for catalysis.