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Research Activities
Overview
The
Dennis group has studied the structure and function of phospholipases
for the past 28 years. We have extensively characterized the cobra
venom phospholipase A2 and from these studies have developed a model
for the action of soluble enzymes at phospholipid surfaces. These studies
have been extended to numerous other phospholipases. We have also explored
the role that these enzymes play in various cell function in macrophages,
aminiotic WISH cells, and in neural tissues.
Since
phospholipase A2 liberates arachidonic acid, it occupies an important
position in the eicosanoid
cascade and is partially responsible for the regulation of prostaglandin
production. The regulation of the production of these compounds has been
shown to be important in inflammation, the onset of premature labor, and
the etiology of various neural degenerative diseases.
Lipid Second Messengers and Phospholipases
Characterization of Phospholipase A2
Inhibitors and Cellular Studies
Membrane Phenomenon and Surface Dilution Kinetics
Other Novel Enzymes
Oxidized Lipids
Webmaster:
Ursula
Kessen, 2005 |