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Joshua D. Brooks, Ph.D.

Postdoctoral Research Associate
9500 Gilman Drive
La Jolla, CA 92093-0601
Phone: (858) 534-8903
Fax: (858) 534 - 7390
email: jdbrooks@ucsd.edu
 
arrived: March 2009
Home Town: Weiner, AR
 

Education:

  • B.A., Mathematics and History, Lyon College, Batesville, AR (2004)
  • Ph.D., Pharmacology, Vanderbilt University, Nashville, TN (2009)
Research Topics:
  • Metabolism of fish oil and role in human diseases
Publications:
  • Musiek EM, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the ?-3 polyunsaturated fatty acid docosahexaenoic acid. J Biol Chem. 2008; 283(29):19927-35.
  • Brooks JD, Milne GL, Yin H, Sanchez SC, Porter NA, Morrow JD. Formation of highly reactive cyclopentenone isoprostane compounds (A3/J3-isoprostanes) in vivo from eicosapentaenoic acid. J Biol Chem. 2008; 283(18):12043-55.
  • Milne GL, Yin H, Brooks JD, Sanchez S, Jackson Roberts L 2nd, Morrow JD. Quantification of F2-isoprostanes in biological fluids and tissues as a measure of oxidant stress. Methods Enzymol. 2007; 433:113-26.
  • Dostalek M, Brooks JD, Hardy KD, Milne GL, Moore MM, Sharma S, Morrow JD, Guengerich FP. In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers. Mol Pharmacol. 2007 Dec; 72(6):1419-24.
  • Yin H, Brooks JD, Gao L, Porter NA, Morrow JD. Identification of novel autooxidation products of the omega-3 fatty acid eicosapentaenoic acid in vitro and in vivo. J Biol Chem. 2007; 282(41):29890-901.
  • Milne GL, Gao L, Brooks JD, Morrow JD. (2007) The Role of Oxidative Stress in Diseases Associated with Overweight and Obesity. Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome. 3, 33-46.
  • Milne GL, Brooks JD, Borntrager HL, Hamm JA, Koestner TH, Peeples AK, and Morrow JD. Isoprostanes and related compounds as markers and mediators of oxidant stress in obesity, diabetes, and other risk factors for atherosclerosis. XIII Congress of the Society for Free Radical Research, 2006.
  • McLaughlin JN, Shen L, Holinstat M, Brooks JD, Dibenedetto E, Hamm HE. Functional selectivity of G protein signaling by agonist peptide and thrombin for the protease-activated receptor-1. J Biol Chem. 2005; 280(23):25048-59.
  • McLaughlin JN, Mazzoni MR, Cleator JH, Earls L, Perdigoto AL, Brooks JD, Muldowney JA 3rd, Vaughan DE, Hamm HE. Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells. J Biol Chem. 2005; 280(23):22172-80.
 
Webmaster: Masada Disenhouse, 2007