Professor of Medicine,
LIPID MAPS Scientific Coordinator

Education:

• B.S. Chemistry, University of Graz, Austria
• M.S. Chemistry, University of Graz, Austria
• Ph.D., Biochemistry, University of Graz, Austria

Current research topics:

Selected Publications:

• Ramprasad MP, Fischer W, Witztum JL, Sambrano GO, Quehenberger O, and Steinberg D. The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68. Proc Natl Acad Sci USA 92:9580-9584, 1995.
• Ottnad E, Parthasarathy S, Sambrano GR, Ramprasad MP, Quehenberger O, Kondratenko N, Green S, and Steinberg D. A macrophage receptor for oxidized low density lipoprotein distinct from the receptor for acetyl low density lipoprotein: Partial purification and role in recognition of oxidatively damaged cells. Proc Natl Acad Sci USA 92:1391-1395, 1995.
• Ramprasad MP, Terpstra V, Kondratenko N, Quehenberger O, and Steinberg D. Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein. Proc Natl Acad Sci USA 93:14833-14838, 1996.
• Green S, Steinberg D, and Quehenberger O. Cloning and expression in Xenopus Oocytes of a mouse homologue of the human acylcoenzyme A:cholesterol acyltransferase and its potential role in metabolism of oxidized LDL. Biochem Biophys Res Commun 218:924-929, 1996.
• Murao K, Terpstra V, Green SR, Kondratenko N, Steinberg D, and Quehenberger O. Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes. J Biol Chem 272:17551-17557, 1997.
• Tangirala RK, Murao K, and Quehenberger O. Regulation of Expression of the human monocyte chemotactic protein-1 receptor (hCCR2) by cytokines. J Biol Chem 272:8050-8056, 1997.
• Han KH, Tangirala RK, Green SR, Quehenberger O. Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1 mediated chemotaxis in human monocytes. A regulatory role for plasma low density lipoprotein. Arterioscler Thromb Vasc Biol 18:1983-1991, 1998.
• Yoshida H, Kondratenko N, Green S, Steinberg D, Quehenberger O. Identification of the lectin-like receptor for oxidized LDL in human macrophages and its potential role as a scavenger receptor. Biochem J 334:9-13, 1998.
• Yoshida H, Quehenberger O, Kondratenko N, Green S, and Steinberg D. Minimally oxidized low-denstiy lipoprotein increases expression of scavenger receptor A, CD36, and macrosialin in resident mouse peritoneal macrophages. Arterioscler Thromb Vasc Biol 18:794-802, 1998.
• Han KH, Green SR, Tangirala RK, Tanaka S, Quehenberger O. Role of the first extracellular loop in the functional activation of CCR2. The first extracellular loop contains distinct domains necessary for both agonist binding and transmembrane signaling. J Biol Chem 274:32055-32062, 1999.
• Han KH, Han KO, Green SR, Quehenberger O. Expression of the monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia: differential effects of plasma lipoproteins on monocyte function. J Lipid Res 40:1053-1063, 1999.
• Han KH, Chang MK, Boullier A, Green SR, Li A, Glass CK, Quehenberger O. Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor ?.
  J Clin Invest 106: 793-802, 2000.
• Napoli C, Quehenberger O, De Nigris F, Abete P, Glass CK, Palinski W. Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells. FASEB J 14: 1996-2007, 2000.
• Boullier A, Gillotte KL, Hörkkö S, Green SR, Friedman P, Dennis EA, Witztum JL, Steinberg D, Quehenberger O. The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein. J Biol Chem 275:9163-9169, 2000.
• Khelef N, Soe TT, Quehenberger O, Beatini N, Tabas I, Maxfield FR. Enrichment of acyl coenzyme A:cholesterol O-acyltransferase near trans-golgi network and endocytic recycling compartment. Arterioscler Thromb Vasc Biol 20:1769-1776, 2000.
• Imachi H, Murao K, Hiramine C, Sayo Y, Sato M, Hosokawa H, Ishida T, Kodama T, Quehenberger O, Steinberg D, Takahara J. Human scavenger receptor B1 is involved in recognition of apoptotic thymocytes by thymic nurse cells. Lab Invest 80:263-270, 2000.
• Kurushima H, Ramprasad M, Kondratenko N, Foster DM, Quehenberger O, Steinberg D. Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophages. J Leukoc Biol 67:104-108, 2000.
• Han K.H. and Quehenberger O. Ligands for peroxisome proliferator-activated receptor inhibit monocyte CCR2 expression stimulated by plasma lipoproteins. Trends Cardiovasc Med 10: 209-216, 2000.
• Marsche G, Levak-Frank S, Quehenberger O, Heller R, Sattler W, Malle E. Identification of the human analog of SR-BI and LOX-1 as receptors for hypochlorite-modified high density lipoprotein on human umbilical venous endothelial cells. FASEB J 15:1095-1097, 2001.
• Gillotte-Taylor K, Boullier A, Witztum JL, Steinberg D, Quehenberger O. Scavenger receptor type B, class I (SR-BI) as a receptor for oxidized low density lipoprotein. J Lipid Res 42:1474-1482, 2001.
• Boullier A, Bird DA, Chang MK, Dennis EA, Friedman P, Gillotte-Taylor K, Horkko S, Palinski W, Quehenberger O, Shaw P, Steinberg D, Terpstra V, Witztum JL. Scavenger receptors, oxidized LDL, and atherosclerosis. Ann NY Acad Sci 947:214-222, 2001.
• Tanaka S, Green SR, Quehenberger O Differential expression of the isoforms for the monocyte chemo-attractant protein-1 receptor, CCR2, in monocytes. Biochem Biophys Res Commun 290:73-80, 2002.
• Han KH, Chen Y, Chang MK, Han YC, Park JH, Green SR, Boullier A, and Quehenberger O. LDL activates signaling pathways leading to an increase in cytosolic free calcium and stimulation of CD11b expression in monocytes. J Lipid Res 44:1332-1340, 2003.
• Balazs Z, Panzenboeck U, Hammer A, Sovic A, Quehenberger O, Malle E, and Sattler W. Uptake and transport of high-density lipoprotein (HDL) and HDL-associated alpha-tocopherol by an in vitro blood-brain barrier model. J Neurochem 89:939-950, 2004.
• Chen Y, Green SR, Ho J, Li A., Almazan F., and Quehenberger O. The mouse CCR2 gene is regulated by two promoters that are responsive to plasma cholesterol and peroxisome proliferator-activated receptor ? ligands. Biochem Biophys Res Commun 332:188-193, 2005.
• Boullier A, Friedman P, Harkewicz R, Hartvigsen K, Green SR, Almazan F, Dennis EA, Steinberg D, Witztum JL, Quehenberger O. Phosphocholine as a pattern recognition ligand for CD36. J Lipid Res 46:969-976, 2005.
• Quehenberger O. Thematic review series: the immune system and atherogenesis. Molecular mechanisms regulating monocyte recruitment in atherosclerosis. J Lipid Res 46:1582-1590, 2005.
• Damas JK, Boullier A, Waehre T, Smith C, Sandberg WJ, Green S, Aukrust P, and Quehenberger O. Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, is elevated in coronary artery disease and is reduced during statin therapy. Arterioscler Thromb Vasc Biol 25:2567-2572, 2005.
• Chen Y, Green SR, Almazan F, and Quehenberger O. The amino-terminus and the third extracellular loop of CX3CR1 contain determinants critical for distinct receptor functions. Mol Pharmacol 69:857-865, 2005.
• Boisvert, WA, Rose DM, Boullier A, Quehenberger O, Sydlaske A, Johnson KA, Curtiss LK, and Terkeltaub R. Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size. Arterioscler Thromb Vasc Biol 26:563-569, 2006.
• Boullier A, Li Y, Quehenberger O, Palinski W, Tabas I, Witztum JL, and Miller YI. Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arterioscler Thromb Vasc Biol 26:1169-1176, 2006.
• von Hahn T, Lindenbach BD, Boullier A, Quehenberger O, Paulson M, Rice CM, and McKeating JA. Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells. Hepatology 43:932-942, 2006.
• Green, SR, Han KH, Chen Y, Almazan F, Charo IF, Miller YI, and Quehenberger O. The CC chemokine MCP-1 stimulates surface expression of CX3CR1 and enhances the adhesion of monocytes to fractalkine/CX3CL1 via p38 MAPK. J Immunol 176:7412-7420, 2006.
• Damas JK, Smith C, Oie E, Fevang B, Halvorsen B, Waehre T, Boullier A, Breland U, Yndestad A, Ovchinnikova O, Robertson AK, Sandberg WJ, Kjekshus J, Tasken K, Froland SS, Gullestad L, Hansson GK, Quehenberger O, Aukrust P. Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization. Arterioscler Thromb Vasc Biol. 27:614-20, 2007.